Life-history stage influences immune investment and oxidative stress in response to environmental heterogeneity in Antarctic fur seals.

Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

Original Publication: London, United Kingdom : Nature Publishing Group UK, [2018]-

Oxidative Stress* ; Fur Seals*/immunology ; Fur Seals*/physiology ; Fur Seals*/metabolism; Animals ; Antarctic Regions ; Female ; Male ; Immunity, Innate ; Hydrocortisone/blood ; Adaptive Immunity

Immune defenses are crucial for survival but costly to develop and maintain. Increased immune investment is therefore hypothesized to trade-off with other life-history traits. Here, we examined innate and adaptive immune responses to environmental heterogeneity in wild Antarctic fur seals. In a fully crossed, repeated measures design, we sampled 100 pups and their mothers from colonies of contrasting density during seasons of contrasting food availability. Biometric and cortisol data as well as blood for the analysis of 13 immune and oxidative status markers were collected at two key life-history stages. We show that immune responses of pups are more responsive than adults to variation in food availability, but not population density, and are modulated by cortisol and condition. Immune investment is associated with different oxidative status markers in pups and mothers. Our results suggest that early life stages show greater sensitivity to extrinsic and intrinsic effectors, and that immunity may be a strong target for natural selection even in low-pathogen environments such as Antarctica.
(© 2024. The Author(s).)

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316099922 Deutsche Forschungsgemeinschaft (German Research Foundation); 396774617 Deutsche Forschungsgemeinschaft (German Research Foundation)

WI4X0X7BPJ (Hydrocortisone)

Date Created: 20240701 Date Completed: 20240702 Latest Revision: 20241217

20250114

PMC11217341

10.1038/s42003-024-06499-6

38951600