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Twist2 contributes to skin regeneration and hair follicle formation in mouse fetuses.
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- معلومة اضافية
- المصدر:
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
- بيانات النشر:
Original Publication: London : Nature Publishing Group, copyright 2011-
- الموضوع:
- نبذة مختصرة :
Unlike adult mammalian wounds, early embryonic mouse skin wounds completely regenerate and heal without scars. Analysis of the underlying molecular mechanism will provide insights into scarless wound healing. Twist2 is an important regulator of hair follicle formation and biological patterning; however, it is unclear whether it plays a role in skin or skin appendage regeneration. Here, we aimed to elucidate Twist2 expression and its role in fetal wound healing. ICR mouse fetuses were surgically wounded on embryonic day 13 (E13), E15, and E17, and Twist2 expression in tissue samples from these fetuses was evaluated via in situ hybridization, immunohistochemistry, and reverse transcription-quantitative polymerase chain reaction. Twist2 expression was upregulated in the dermis of E13 wound margins but downregulated in E15 and E17 wounds. Twist2 knockdown on E13 left visible marks at the wound site, inhibited regeneration, and resulted in defective follicle formation. Twist2-knockdown dermal fibroblasts lacked the ability to undifferentiate. Furthermore, Twist2 hetero knockout mice (Twist + /-) formed visible scars, even on E13, when all skin structures should regenerate. Thus, Twist2 expression correlated with skin texture formation and hair follicle defects in late mouse embryos. These findings may help develop a therapeutic strategy to reduce scarring and promote hair follicle regeneration.
(© 2024. The Author(s).)
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- Grant Information:
JP 20K18422 Japan Society for the Promotion of Science
- Contributed Indexing:
Keywords: Hair follicle formation; Scar; Skin regeneration; Twist2; Wound healing
- الرقم المعرف:
0 (Repressor Proteins)
0 (Twist-Related Protein 1)
0 (Twist-Related Protein 2)
0 (Twist2 protein, mouse)
- الموضوع:
Date Created: 20240513 Date Completed: 20240513 Latest Revision: 20240711
- الموضوع:
20240711
- الرقم المعرف:
PMC11091223
- الرقم المعرف:
10.1038/s41598-024-60684-5
- الرقم المعرف:
38740788
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