Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Processing Request
Global transmission of broad-host-range plasmids derived from the human gut microbiome.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Processing Request
- معلومة اضافية
- المصدر:
Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
- بيانات النشر:
Publication: 1992- : Oxford : Oxford University Press
Original Publication: London, Information Retrieval ltd.
- الموضوع:
- نبذة مختصرة :
Broad-host-range (BHR) plasmids in human gut bacteria are of considerable interest for their ability to mediate horizontal gene transfer (HGT) across large phylogenetic distance. However, the human gut plasmids, especially the BHR plasmids, remain largely unknown. Here, we identified the plasmids in the draft genomes of gut bacterial isolates from Chinese and American donors, resulting in 5372 plasmid-like clusters (PLCs), of which, 820 PLCs (comPLCs) were estimated with > 60% completeness genomes and only 155 (18.9%) were classified to known replicon types (n = 37). We observed that 175 comPLCs had a broad host range across distinct bacterial genera, of which, 71 were detected in at least two human populations of Chinese, American, Spanish, and Danish, and 13 were highly prevalent (>10%) in at least one human population. Haplotype analyses of two widespread PLCs demonstrated their spreading and evolutionary trajectory, suggesting frequent and recent exchanges of the BHR plasmids in environments. In conclusion, we obtained a large collection of plasmid sequences in human gut bacteria and demonstrated that a subset of the BHR plasmids can be transmitted globally, thus facilitating extensive HGT (e.g. antibiotic resistance genes) events. This study highlights the potential implications of the plasmids for global human health.
(© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.)
- References:
Nat Commun. 2018 Nov 30;9(1):5114. (PMID: 30504855)
Bioinformatics. 2017 Feb 15;33(4):475-482. (PMID: 28003256)
Bioinformatics. 2018 Sep 1;34(17):i884-i890. (PMID: 30423086)
Bioinformatics. 2010 Oct 1;26(19):2460-1. (PMID: 20709691)
Genome Res. 2003 Nov;13(11):2498-504. (PMID: 14597658)
Nat Biotechnol. 2019 Feb;37(2):179-185. (PMID: 30718868)
Nat Methods. 2015 Jan;12(1):59-60. (PMID: 25402007)
Nucleic Acids Res. 2021 Jan 8;49(D1):D783-D791. (PMID: 33074335)
Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5033-8. (PMID: 21383187)
Microbiome. 2021 Jun 25;9(1):144. (PMID: 34172093)
J Glob Antimicrob Resist. 2019 Mar;16:215-219. (PMID: 30342929)
Mol Biol Evol. 2017 Dec 1;34(12):3299-3302. (PMID: 29029172)
Gut Microbes. 2010 Nov-Dec;1(6):415-31. (PMID: 21468227)
BMC Bioinformatics. 2021 Jun 26;22(1):349. (PMID: 34174810)
Genome Res. 2019 Jun;29(6):961-968. (PMID: 31048319)
Bioinformatics. 2009 Jun 1;25(11):1422-3. (PMID: 19304878)
Nucleic Acids Res. 2021 Mar 18;49(5):2655-2673. (PMID: 33590101)
Nat Commun. 2013;4:2304. (PMID: 23942190)
Nat Commun. 2020 Jan 7;11(1):95. (PMID: 31911609)
Bioinformatics. 2015 May 15;31(10):1674-6. (PMID: 25609793)
Nucleic Acids Res. 2020 Jan 8;48(D1):D517-D525. (PMID: 31665441)
Trends Genet. 2000 Jun;16(6):276-7. (PMID: 10827456)
Annu Rev Microbiol. 2011;65:411-29. (PMID: 21682646)
Methods Mol Biol. 2020;2075:265-283. (PMID: 31584169)
Nucleic Acids Res. 2018 Apr 6;46(6):e35. (PMID: 29346586)
Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20568-20573. (PMID: 31548387)
Front Microbiol. 2017 Sep 26;8:1852. (PMID: 29018426)
Nucleic Acids Res. 2009 Jan;37(Database issue):D233-8. (PMID: 18838391)
BMC Bioinformatics. 2011 Nov 09;12:436. (PMID: 22070249)
FEMS Microbiol Lett. 2013 Nov;348(2):87-96. (PMID: 23980652)
J Antimicrob Chemother. 2018 May 1;73(5):1121-1137. (PMID: 29370371)
J Bacteriol. 1988 Mar;170(3):1319-24. (PMID: 3343220)
Nat Commun. 2019 Mar 8;10(1):1124. (PMID: 30850636)
J Comput Biol. 2012 May;19(5):455-77. (PMID: 22506599)
Antimicrob Agents Chemother. 2014 Jul;58(7):3895-903. (PMID: 24777092)
Nat Methods. 2007 Jan;4(1):55-61. (PMID: 17128268)
Nat Microbiol. 2021 Mar;6(3):354-365. (PMID: 33495623)
Nucleic Acids Res. 2002 Apr 1;30(7):1575-84. (PMID: 11917018)
Nat Commun. 2020 May 15;11(1):2452. (PMID: 32415210)
Nat Commun. 2020 Jul 17;11(1):3602. (PMID: 32681114)
Nat Med. 2019 Sep;25(9):1442-1452. (PMID: 31477907)
Nat Biotechnol. 2014 Aug;32(8):834-41. (PMID: 24997786)
Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19126-31. (PMID: 19855009)
Gigascience. 2019 Jun 1;8(6):. (PMID: 31220250)
BMC Bioinformatics. 2010 Mar 08;11:119. (PMID: 20211023)
mSphere. 2020 Aug 19;5(4):. (PMID: 32817379)
Nucleic Acids Res. 2019 Jan 8;47(D1):D687-D692. (PMID: 30395255)
Genome Biol. 2016 Jun 20;17(1):132. (PMID: 27323842)
Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13880-5. (PMID: 23898187)
PLoS One. 2014 Feb 04;9(2):e87924. (PMID: 24503942)
Nat Microbiol. 2016 Sep 19;1:16161. (PMID: 27643971)
FEMS Microbiol Ecol. 2016 Mar;92(3):. (PMID: 26850157)
BMC Bioinformatics. 2009 Dec 15;10:421. (PMID: 20003500)
Nucleic Acids Res. 2004 Mar 19;32(5):1792-7. (PMID: 15034147)
Nucleic Acids Res. 2018 Jul 2;46(W1):W95-W101. (PMID: 29771380)
Nature. 2013 Jan 3;493(7430):45-50. (PMID: 23222524)
- الموضوع:
Date Created: 20230607 Date Completed: 20230828 Latest Revision: 20231004
- الموضوع:
20231004
- الرقم المعرف:
PMC10450197
- الرقم المعرف:
10.1093/nar/gkad498
- الرقم المعرف:
37283060
No Comments.