Subacute multisystemic toxoplasmosis in a captive black-and-gold howler monkey (Alouatta caraya) indicates therapy challenging.

Publisher: Wiley Country of Publication: Denmark NLM ID: 0320626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0684 (Electronic) Linking ISSN: 00472565 NLM ISO Abbreviation: J Med Primatol Subsets: MEDLINE

Publication: Copenhagen : Wiley
Original Publication: Basel, New York, Karger.

Alouatta* ; Alouatta caraya* ; Toxoplasma* ; Toxoplasmosis*; Animals ; Polymerase Chain Reaction

A 10-year-old black howler monkey presented with a 36-day subacute clinicopathological picture of fever, prostration, inappetence, intestinal hypomotility, and emaciation. Therapy was trimethoprim-sulfamethoxazole with streptomycin. The liver, lungs, lymph nodes, and spleen presented lesions. Toxoplasma gondii isolation and PCR determined the diagnosis, and indirect fluorescent antibody tests confirmed an increase in antibody titers.
(© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Bicca-Marques J, Alves SL, Boubli J, Cornejo FM, Cortes-Ortíz L, Jerusalinsky L, Ludwig G, Martins V, Melo FR, Messias M, Miranda J, Rumiz DI, Rímoli J, Talebi M, Wallace R, Cunha R, Valle RR. Alouatta caraya. The IUCN red list of threatened species 2020. 2020. e.T41545A17924308.
Paula NF, Dutra KS, Oliveira AR, et al. Host range and susceptibility to toxoplasma gondii infection in captive neotropical and old-world primates. J Med Primatol. 2020;49:202-210.
Innes EA. Toxoplasmosis: comparative species susceptibility and host immune response. Comp Immunol Microbiol Infect Dis. 1997;20:131-138.
Dubey JP. Toxoplasma gondii infections in non-human primates. Toxoplasmosis of Animals and Humans. 3rd ed. Taylor and Francis; 2022:355-368.
Homan WL, Vercammen M, De Braekeleer J, Verschueren H. Identification of a 200- to 300-fold repetitive 529 bp DNA fragment in toxoplasma gondii, and its use for diagnostic and quantitative PCR. Int J Parasitol. 2000;30:69-75.
Courtney A, ed. Basic Fluid Therapy. Pocket Handbook of Nonhuman Primate Clinical Medicine. CRCPress; 2013:59-69.
Camargo ME. Improved technique of direct immunofluorescence for serological diagnosis of toxoplasmosis. Revta Inst Med Trop. 1964;1964(6):117-118.
Pereira GO, Pereira AHB, Brito MDF, Pescador CA, Ubiali DG. Toxoplasma gondii induced abortions in a goat herd in Rio de Janeiro. Brazil Ciência Rural. 2021;51:e20200568.
Dubey JP. Refinement of pepsin digestion method for isolation of toxoplasma gondii from infected tissues. Vet Parasitol. 1998;74:75-77.
Moreira FRR, D'arc M, Mariani D, et al. Epidemiological dynamics of SARS-CoV-2 VOC gamma in Rio de Janeiro, Brazil. Virus Evol. 2021;7:veab087.
Hu H, Jung K, Wang Q, Saif LJ, Vlasova AN. Development of a one-step RT-PCR assay for detection of pancoronaviruses (α-, β-, γ-, and δ-coronaviruses) using newly designed degenerate primers for porcine and avian fecal samples. J Virol Methods. 2018;256:116-122.
Domingo C, Patel P, Yillah J, et al. Advanced yellow fever virus genome detection in point-of-care facilities and reference laboratories. J Clin Microbiol. 2012;50:4054-4060.
Gyimesi ZS, Lappin MR, Dubey JP. Application of assays for the diagnosis of toxoplasmosis in a colony of woolly monkeys (Lagothrix lagotricha). J Zoo Wildl Med. 2006;37:276-280.
Casagrande RA, Silva TCE, Pescador CA, et al. Toxoplasmose em primatas neotropicais: estudo retrospectivo de sete casos. Pesq Vet Bras. 2013;33:94-98.
Santana CH, Oliveira AR, Santos DO, et al. Genotyping of toxoplasma gondii in a lethal toxoplasmosis outbreak affecting captive howler monkeys (Alouatta sp.). J Med Primatol. 2020;50:99-107.
Nguyen BT, Stadtsbaeder S. Comparative effects of cotrimoxazole (trimethoprim-sulphamethoxazole), pyrimethamine-sulphadiazine and spiramycin during avirulent infection with toxoplasma gondii (Beverley strain) in mice. Br J Pharmacol. 1983;79:923-928.
Pires JS, Ribeiro CT, Carvalho Filho PR, Pissinatti A, Flausino W, Lopes CWG. Infection by toxoplasma gondii in neotropical non-human primates. Pesq Vet Bras. 2012;32:1041-1044.
Silva RC, Machado GP, Cruvinel TMA, Cruvinel CA, Langoni H. Frequency of toxoplasma gondii antibodies in tufted capuchin monkeys (Cebus apella nigritus) from an ecological station in the state of São Paulo. Brazil Pesq Vet Bras. 2013;33:251-253.
Minervino AHH, Cassinelli ABM, Souza AJS, et al. Detection of toxoplasma gondii antibodies in captive nonhuman primates in the Amazon region. Brazil J Med Primatol. 2017;46:343-346.
Ferreira DRA, Ribeiro VO, Laroque PO, et al. Risk factors associated with toxoplasma gondii infection in captive Sapajus spp. Am J Primatol. 2015;77:558-562.

Keywords: Platyrrhini; conservation; veterinary pathology; wildlife medicine

Date Created: 20220607 Date Completed: 20221115 Latest Revision: 20221220

20240829

10.1111/jmp.12600

35670089