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The Association between Certain Proinflammatory Biomarkers and Body Composition in a Group of Overweight Students at the University of Jordan.
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- معلومة اضافية
- Alternate Title:
العلاقة بين بعض المؤشرات الحيوية الدالة على الالتهاب ومكونات الجسم لدى مجموعة من ذوي الوزن الزائد من طلبة الجامعة الأردنية
- الموضوع:
- نبذة مختصرة :
The objectives of this study were to determine the circulatory levels of proinflammatory biomarkers including interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-), and high sensitivity-C reactive protein (hs-CRP) in a group of overweight (OWT) and normal body weight (NWT) students, and to examine their association with adiposity assessed by using classical anthropometric measurements and bioelectrical impedance analysis (BIA). A case-control study was conducted among 90 (45 OWT and 45 NWT) students (1825 years) recruited from all faculties of the University of Jordan, Jordan. Height, weight, Waist circumference (WC) and hip circumference (HC) were measured using standard procedures, whereas percent fat mass (%FM) and percent fat free mass (%FFM) were determined using BIA. Serum levels of the examined proinflammatory biomarkers were also determined. Results showed that mean concentration of hs-CRP (0.79 ±0.85) and IL-6 (7.72 ±2.31) in OWT were significantly higher than that in NWT counterparts (0.45 ±0.52, 6.38 ±1.37; respectively, P<0.05); whereas no significant differences were observed in the mean concentration of IL-1β and TNF- between the two groups. CRP was significantly associated with BMI (r=0.538, P<0.01), weight (r=0.445, P<0.01), waist circumference (r=0.440, P<0.01), waist-to-hip ratio (r=0.229, P<0.05), and %FM (r=0.266, P<0.05). Whereas, IL-6 was positively correlated with %FM in males (r=0.306, P<0.05) and negatively correlated with %FFM in females (r=-0.297, P<0.05). No significant association was observed between any of the body composition measurements and IL-1β and TNF-α. In conclusion, progressive increase in body fat is responsible for the activation of the immune system even before reaching the obesity stage. [ABSTRACT FROM AUTHOR]
- نبذة مختصرة :
هدفت هذة الدراسة إلى تقدير مستويات عدد من المؤشرات الحيوية المحفزة للالتهاب: انترلوكين 1 بيتا (1β-IL )وانترلوكين 6 تنخ (α-TNF )وبروتين سي التفاعلي عالي الحساسية (CRP-hs )لدى مجموعة من طلبة (6-IL )ر الأورام ألفا وعامل ّ الس الخصر ُ الجامعة الأردنية وهدفت أيضا إلى مقارنة الطرق التقليدية في تقييم منة كمؤشر كتلة الجسم ووزن الجسم ومحيط ونسبة الخصر إلى الورك مع الطريقة المتقدمة والمتمثلة في تحليل مقاومة مرور الشحنات الكهربائية في الأنسجة الحية، وفعالية ُمنة كلتا الطريقتين في تقييم العلاقة بين الس الأولى. تكونت عينة الدراسة من 90 طالبا ُمنة والاستجابة المناعية بمراحل الس وطالبة (45 ذوي وزن زائد و45 ذوي وزن طبيعي). تكونت كل مجموعة من 22 طالبا و 23 طالبة (18-25 سنة) . تم أخذ القياسات الجسمية، وتحليل مكونات بنية الجسم وتقدير مستويات محفزات الالتهاب لكل مشارك بالدراسة.أظهرت نتائج الدراسة وجود فرق معنوي ذو دلالة إحصائية بين متوسط مستويات CRP-hs بين الطلاب في كلتا المجموعتين (05.0
- نبذة مختصرة :
Copyright of Jordan Journal of Agricultural Sciences is the property of University of Jordan and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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